Prosed ED Delayed-Release Tablets

Pronunciation: A-troe-peen/ben-ZOE-ik AS-id/hye-oh-SYE-a-meen/meth-EN-a-meen/METH-i-leen/FEN-ill sa-LI-si-late
Generic Name: Atropine/Benzoic Acid/Hyoscyamine/Methenamine/Methylene Blue/Phenyl Salicylate
Brand Name: Prosed ED and Uritact-EC

Prosed ED Delayed-Release Tablets are used for:

Treating painful and irritating symptoms of the urinary tract due to urinary tract infections or diagnostic procedures.

Prosed ED Delayed-Release Tablets are a urinary antiseptic, urinary acidifier, analgesic, and anticholinergic combination. It works by helping to kill bacteria in the urine, decreasing pain and inflammation, and reducing muscle spasms in the urinary tract. These actions work together to help relieve discomfort while urinating.

Do NOT use Prosed ED Delayed-Release Tablets if:

• you are allergic to any ingredient in Prosed ED Delayed-Release Tablets


• you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin, other salicylate medicines, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)


• you have angle-closure glaucoma, problems with your esophagus, bowel motility problems, a blockage of your bladder or bowel, severe intestinal problems (eg, ulcerative colitis), severe bleeding, flu or chickenpox, myasthenia gravis, severe kidney problems, or you are severely dehydrated


• you are taking a sulfonamide (eg, sulfamethoxazole)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prosed ED Delayed-Release Tablets:

Some medical conditions may interact with Prosed ED Delayed-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have constipation, diarrhea, an infection of the stomach or bowel, a hiatal hernia, or stomach ulcers


• if you have nervous system problems, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, gout, influenza, Kawasaki syndrome, rheumatic disease, open-angle glaucoma, risk factors for angle-closure glaucoma, kidney or liver problems, an enlarged prostate, bladder problems, or you are unable to urinate


• if you have a history of stroke or brain blood vessel problems (eg, aneurysm), an irregular heartbeat, heart blood vessel problems, congestive heart failure, heart valve problems, or other heart problems


• if you are on a low-salt diet

Some MEDICINES MAY INTERACT with Prosed ED Delayed-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, benztropine) because they may increase the risk of Prosed ED Delayed-Release Tablets's side effects.


• Ketoconazole because it may decrease Prosed ED Delayed-Release Tablets's effectiveness.


• Monoamine oxidase inhibitors (MAOIs)or narcotic pain medicine (eg, codeine) because the risk of serious side effects may be increased.


• Medicine for myasthenia gravis (eg, ambenonium), phenothiazines (eg, chlorpromazine), sulfonamides (eg, sulfamethoxazole), thiazide diuretics (eg, hydrochlorothiazide), or urinary alkalinizers (eg, sodium bicarbonate) because their effectiveness may be decreased by Prosed ED Delayed-Release Tablets.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prosed ED Delayed-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prosed ED Delayed-Release Tablets:

Use Prosed ED Delayed-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Prosed ED Delayed-Release Tablets by mouth with or without food.


• Swallow Prosed ED Delayed-Release Tablets whole. Do not break, crush, or chew before swallowing.


• Do not take an antacid or antidiarrheal medicine (eg, loperamide) within 1 hour before or after you take Prosed ED Delayed-Release Tablets.


• Drinking extra fluids while you are taking Prosed ED Delayed-Release Tablets are recommended. Check with your doctor for instructions.


• If you miss a dose of Prosed ED Delayed-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prosed ED Delayed-Release Tablets.

Important safety information:

• Prosed ED Delayed-Release Tablets may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Prosed ED Delayed-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.


• Prosed ED Delayed-Release Tablets may discolor the urine or stools a blue-green color. This is normal and not a cause for concern.


• Prosed ED Delayed-Release Tablets contains salicylate. Salicylates have been linked to a serious illness called Reye syndrome. Do not give Prosed ED Delayed-Release Tablets to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.


• Use Prosed ED Delayed-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially excitement, agitation, drowsiness, and confusion.


• Prosed ED Delayed-Release Tablets should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Prosed ED Delayed-Release Tablets can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prosed ED Delayed-Release Tablets while you are pregnant. Prosed ED Delayed-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use Prosed ED Delayed-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Prosed ED Delayed-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry mouth; flushing; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; difficulty urinating; dizziness; fast or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Prosed ED Delayed-Release Tablets:

Store Prosed ED Delayed-Release Tablets between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prosed ED Delayed-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Prosed ED Delayed-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Prosed ED Delayed-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Prosed ED Delayed-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Prosed ED resources

• Prosed ED Use in Pregnancy & Breastfeeding
• Prosed ED Drug Interactions
• Prosed ED Support Group
• 16 Reviews for Prosed ED - Add your own review/rating

Compare Prosed ED with other medications

• Urinary Tract Infection

Hemodialysis Medications

Definition of Hemodialysis: Hemodialysis a medical procedure that uses a specialized machine to filter waste products from the blood, while restoring its normal constituents. Hemodialysis is needed to perform the work of the kidneys if they can no longer function effectively.

Topics under Hemodialysis

• Hemodialysis Anticoagulation (0 drugs)

Learn more about Hemodialysis

Micromedex Care Notes:

• Peritoneal Dialysis Catheter Care

Drug List:

Cold Spot Point Relief

Generic Name: menthol

Dosage Form: ointment
Cold Spot Point Relief Pain relieving Roll On - 3 oz.

Active Ingredients: Menthol

Inactive Ingredients: deionized water, arnica, chondroitin sulfate, citirc acid, euclayptus oil, glucosamine sulfate, ilex paraguariesis leaf, isopropyl alcohol, peppermint oil, dimethyl sulfone, polysorbate-20, SD alcohol 40B.

Keep out of reach of children. If swallowed consult physician

Warnings Section: For external use only, avoid contact with eyes, do not apply to open wounds or damaged skin, if symptoms persist for more than seven days discontinue use and consult physician, keep out of reach of children and if swallowed consult physician, do not bandage tightly.

pain relief

Use: For temporary relief of minor aches and pains of the muscles and joints associated with simple backache, arthritis, bruises, strains and/or sprains.

  Apply directly to effected area. Do not use more than four times per day.
ColdSpot Point Relief Pain Relieving spray, all natural ingredients.

COLD SPOT  POINT RELIEF menthol  ointment

Product Information Product Type HUMAN OTC DRUG NDC Product Code (Source) 51452-002 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength MENTHOL (MENTHOL) MENTHOL 13 mL  in 90 mL

Inactive Ingredients Ingredient Name Strength WATER   ARNICA CORDIFOLIA FLOWER   CHONDROITIN SULFATE (BOVINE)   EUCALYPTUS GLOBULUS LEAF   GLUCOSAMINE SULFATE   ILEX PARAGUARIENSIS LEAF   CARBOMER 1342   peppermint oil   DIMETHYL SULFONE   POLYSORBATE 20   ALCOHOL

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 51452-002-03 90 mL In 1 BOTTLE None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
OTC monograph final	part341	08/24/2010

Labeler - Fabrication Enterprises (070577218)

Registrant - Fabrication Enterprises (070577218)

Establishment
Name	Address	ID/FEI	Operations
Fabrication Enterprises		070577218	relabel

Establishment
Name	Address	ID/FEI	Operations
pure source		969241041	manufacture

Revised: 10/2010Fabrication Enterprises

More Cold Spot Point Relief resources

• Cold Spot Point Relief Side Effects (in more detail)
• Cold Spot Point Relief Use in Pregnancy & Breastfeeding
• 0 Reviews for Cold Spot Point Relief - Add your own review/rating

Compare Cold Spot Point Relief with other medications

• Cough
• Pain

Succimer

Pronunciation: SUX-ih-mer
Generic Name: Succimer
Brand Name: Chemet

Succimer is used for:

Treating lead poisoning.

Succimer is a lead chelator. It works by trapping lead in the body and removing it in the urine.

Do NOT use Succimer if:

• you are allergic to any ingredient in Succimer

Contact your doctor or health care provider right away if any of these apply to you.

Before using Succimer:

Some medical conditions may interact with Succimer. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are dehydrated or you have liver or kidney problems

Some MEDICINES MAY INTERACT with Succimer. However, no specific interactions with Succimer are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Succimer may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Succimer:

Use Succimer as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Succimer may be taken with or without food.


• Swallow Succimer whole. Do not break, crush, or chew before swallowing.


• If you have difficulty swallowing the capsule, empty the contents onto a small amount of soft food. Eat the food right away without chewing. You may also eat the contents of the capsule from a spoon. After eating, follow with a fruit drink.


• Drinking extra fluids while you are taking Succimer is recommended. Check with your doctor for instructions.


• If you miss a dose of Succimer, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Succimer.

Important safety information:

• Succimer may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Succimer. Using Succimer alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• It is important to identify and remove the source of lead poisoning from your environment.


• Do not exceed the recommended dose or take Succimer for longer than prescribed without checking with your doctor.


• Succimer may low your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.


• Succimer may interfere with certain lab tests. Be sure your doctor and laboratory personnel know you are taking Succimer.


• Succimer may cause incorrect test results with some urine ketone tests. Check with your doctor before you adjust the dose of your diabetes medicine or change your diet.


• LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.


• Use Succimer with extreme caution in CHILDREN younger than 12 months of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Succimer during pregnancy. It is unknown if Succimer is excreted in breast milk. Do not breast-feed while taking Succimer.

Possible side effects of Succimer:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; back, flank, rib, kneecap, leg, or head pain; decreased urination; diarrhea; dizziness; drowsiness; headache; heavy head; hemorrhoids; loose stools; metallic taste in mouth; nausea; numbness or tingling of the skin; runny nose; stomach pain or cramps; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cold symptoms (eg, stuffy nose, cough); fever, chills, or sore throat; irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Succimer side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; convulsion; difficulty breathing; incoordination.

Proper storage of Succimer:

Store Succimer at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Succimer out of the reach of children and away from pets.

General information:

• If you have any questions about Succimer, please talk with your doctor, pharmacist, or other health care provider.


• Succimer is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Succimer. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Succimer resources

• Succimer Side Effects (in more detail)
• Succimer Use in Pregnancy & Breastfeeding
• Succimer Support Group
• 0 Reviews for Succimer - Add your own review/rating

• Succimer Monograph (AHFS DI)


• Succimer Professional Patient Advice (Wolters Kluwer)


• succimer Concise Consumer Information (Cerner Multum)


• succimer Advanced Consumer (Micromedex) - Includes Dosage Information


• Chemet Prescribing Information (FDA)

Compare Succimer with other medications

• Lead Poisoning, Severe

Instanyl 50, 100 and 200 mcg / dose nasal spray

Instanyl 50 micrograms/dose nasal spray, solution

Instanyl 100 micrograms/dose nasal spray, solution

Instanyl 200 micrograms/dose nasal spray, solution

Fentanyl

Read all of this leaflet carefully before you start using this medicine.

• Keep this leaflet. You may need to read it again.


• If you have any further questions, ask your doctor or pharmacist.


• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.


• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

In this leaflet:

• 1. What Instanyl is and what it is used for


• 2. Before you use Instanyl


• 3. How to use Instanyl


• 4. Possible side effects


• 5. How to store Instanyl


• 6. Further information

What Instanyl Is And What It Is Used For

Instanyl belongs to a group of strong painkillers called opioids. Opioids act by blocking the pain signals to the brain.

Instanyl acts very fast and is used for relieving breakthrough pain in adult cancer patients already being treated with opioids for their usual pain. Breakthrough pain is an additional sudden pain that occurs despite you having taken your usual
opioid pain relieving medicines.

Before You Use Instanyl

Do not use Instanyl:

• if you are hypersensitive (allergic) to fentanyl or any of the other ingredients of Instanyl


• if you have never been treated with opioids before (e.g. codeine, fentanyl, hydromorphone, morphine, oxycodone, pethidine)


• if you have serious difficulties breathing or suffer from a serious obstructive lung disease


• if you have previously received facial radiotherapy


• if you suffer from recurrent episodes of nose bleeding

Take special care with Instanyl

• if you suffer from a long-term obstructive lung disease, your breathing may be impaired by Instanyl


• if you have problems with you heart especially slow heart rate, muscle weakness or low blood volume


• if you have problems with your liver or kidneys


• if you have problems with your brain function, e.g. due to a brain tumour, a head injury or increased intracranial pressure


• if you use other nasal spray products e.g. for common cold and allergy

If you experience difficulties breathing while being treated with Instanyl, it is important that you contact your doctor or hospital immediately.

If you expeience recurrent nose bleeding or nasal discomfort whilst being treated with Instanyl, you must contact you doctor, who will consider alternative treatment for your breakthrough pain.

If you think you are becoming dependent on Instanyl, it is important that you inform your doctor.

Instanyl should not be used in children and adolescents under 18 years of age.

Using other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Instanyl may affect or be affected by other medicines.

Special care should be taken if you are treated with any of the following medicines:

• Any medicines which might normally make you sleepy (have a sedative effect) such as sleeping pills, medicines to treat anxiety, antihistamines, or tranquillisers


• Any medicines that might have an effect on the way in which your body breaks down Instanyl, such as
  
  
  • ritonavir, nelfinavir, amprenavir, and fosamprenavir (medicines that help control HIV infection)
  • CYP3A4 inhibitors such as ketoconazole, itraconazole, or fluconazole (used for treatment of fungal infections),
  • troleandomycine, clarithromycine, or erythromycine (medicines for treatment of bacterial infections),
  • aprepitant (used to treat severe nausea)
  • diltiazem and verapamil (medicines for treatment of high blood pressure or heart diseases)


• Medicines called monoamine-oxidase (MAO) inhibitors (used for severe depression), even if you have been treated with one in the past 2 weeks


• Medicines called partial agonist/antagonists e.g. buprenorphine, nalbuphine and pentazocine (medicines for treatment of pain)


• Other medicines taken via the nose, especially oxymetazoline, xylometazoline and similar medicines, which are used for relief of nose congestions.

Using Instanyl with food and drink

Do not drink alcohol whilst being treated with Instanyl, as it can increase the risk of experiencing dangerous side effects.

Pregnancy and breast-feeding

Ask your doctor or pharmacist for advice before taking any medicine.

Instanyl should not be used during pregnancy unless you have discussed this with your doctor.

Instanyl should not be used during childbirth because fentanyl may cause serious breathing problems in the new-born child.

Instanyl should not be used if you are breast-feeding unless you have discussed this with your doctor.

Fentanyl can pass into the breast milk and may cause side effects to the breast-fed child.

Driving and using machines

You should not drive or use machinery whilst being treated with Instanyl. Instanyl can cause dizziness and drowsiness, which may affect your ability to drive or use machines.

How To Use Instanyl

Always use Instanyl exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure about the treatment or if you have additional questions.

The dose of Instanyl is independent of your usual cancer pain treatment.

When you first start using Instanyl, your doctor will work with you to find the dose that will relieve your breakthrough pain.

The initial dose is one puff of 50 micrograms in one nostril each time you have an episode of breakthrough pain. During the determination of your right dose, your doctor may instruct you to change to a higher dose.

If your breakthrough pain is not relieved after 10 minutes, you may use only one more puff for this episode.

You should wait four hours before treating the next episode of breakthrough pain. You can use Instanyl to treat up to four episodes of breakthrough pain per day.

If you experience more than four episodes of breakthrough pain per day, you should contact your doctor, as your usual cancer pain treatment may have to be changed.

In order to keep track of the number of doses of Instanyl used, you should use the tick-boxes in the booklet placed on top of the child-resistant outer box.

Do not change the dose of Instanyl or your other pain medicines on your own. Change in dose must be done together with your doctor.

Instanyl is for nasal use

Instanyl should be used in the following way:

• You sit or stand in an upright position


• Remove the dust cap from the spray


• Before using the pump for the first time: Pump the spray until a fine mist appears (3 to 4 pumps of the nasal spray are required). It is important that you avoid pointing the spray in the direction of other people.


• Hold the spray upright


• Bend your head slightly forward


• Close one nostril by placing your finger against the side of your nose and insert the spray tip into the other nostril


• Press the pump once quickly while inhaling through the nose


• Always place Instanyl in the child-resistant box after use

If you have not used Instanyl for more than 7 days the pump must be sprayed once in the air before the next dose is taken.

If you use more Instanyl than you should or if you think someone has accidently used Instanyl

You should contact your doctor, hospital or emergency room for assessment of the risk and for advice if you have taken more Instanyl than you should.

Symptoms of overdose are:

Sleepiness, drowiness, dizziness, reduced body temperature, slow heart beat, difficulties coordinating arms and legs.

In serious cases taking too much Instanyl may cause coma, sedation, convulsions or severe breathing difficulties.

If you feel any of the above symptoms you should seek immediate medical assistance.

Note to carers

If you see the person taking Instanyl suddenly acting slowly, having difficulties breathing or if you have a difficulties waking the person up you should:

• Immediately call for emergency help


• While waiting for the emergency help, you must try to keep the person awake by talking to or gently shaking the person now and then


• If the person has difficulty breathing, prompt the person to breathe in every 5-10 seconds


• If the person has stopped breathing, you should attemt to resuscitate her/him until emergency help arrives

If you think someone has accidentally taken Instanyl, please seek immediate medical assistance. Try to keep the person awake until emergency help arrives.

If someone has accidentally taken Instanyl, they may have the same symptoms as described above for overdose.

If you forget to use Instanyl

If the breakthrough pain is still ongoing, you may take Instanyl as prescribed by your doctor. If the breakthrough pain has stopped, do not take Instanyl until the next episode of breakthrough pain occurs.

If you stop using Instanyl

You should discontinue Instanyl when you no longer have any breakthrough pain.

You should however continue to take your usual pain relieving medicine to treat your cancer pain. Contact your doctor to confirm the correct dose of your usual medicine if you are not sure.

You may experience withdrawal symptoms similar to the possible side effects of Instanyl when discontinuing Instanyl. If you experience withdrawal symptoms, you should contact your doctor. Your doctor will evaluate if you need medication to reduce or eliminate the withdrawal symptoms.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible Side Effects

Like all medicines, Instanyl can cause side effects, although not everybody gets them.

The side effects will often stop or reduce in intensity with continued use of the product.

If any of the following very serious side effects occur you should discontinue the treatment and immediately contact your doctor, a hospital or an emergency room:

Severe difficulties breathing, a rattling sound when you breathe in, convulsive pain or extreme dizziness.

The frequency of possible side effects listed below is defined using the following convention:

Very common (affects more than 1 user in 10)

Common (affects 1 to 10 users in 100)

Uncommon (affects 1 to 10 users in 1,000)

Rare (affects 1 to 10 users in 10,000)

Very rare (affects less than 1 user in 10,000)

Not known (frequency cannot be estimated from the available data)

Side effects reported after use of Instanyl:

Common side effects:
Sleepiness, dizziness even with difficulties keeping balance, headache, irritation of the throat, nausea, vomiting, flushing, feeling very warm, excessive sweating.

Uncommon side effects:
Dependency on the medicine, sleeplessness, drowsiness, convulsive muscle contractions, abnormal sensation of the skin even unpleasant, change of taste, motion sickness, low blood pressure, difficulties breathing, nose bleeds, nasal ulcer, runny nose, constipation, inflammation of the mouth, dry mouth, skin pain, itching of the skin, fever.

You should tell your doctor if you experience recurrent episodes of nose bleeding or nasal discomfort.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Instanyl

The pain-relieving medicine in Instanyl is very strong and can be life-threatening to children. Instanyl must be kept out of reach and sight of children. Always place the nasal spray in the child-resistant box after use. Do not use Instanyl after the expiry date which is stated on the bottle as EXP. Store below 30°C. Keep the bottle stored upright. Do not freeze. If Instanyl nasal spray is frozen the spray pump may crack. If uncertain of how the pump has been stored, you should check the spray pump before use.

Instanyl that has passed the expiry date or is no longer required, may still contain enough medicine to be harmful to other people, especially children. Instanyl should not be disposed of via wastewater or household waste. Any used or unused bottles should be systematically discarded according to local requirements or returned to the pharmacy in the child-resistant outer box. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information

What Instanyl contains

The active substance is fentanyl. The content is:

50 micrograms/dose: 1 ml contains fentanyl citrate equivalent to 500 micrograms fentanyl. 1 puff (100 microlitre) contains 50 micrograms fentanyl.

100 micrograms/dose: 1 ml contains fentanyl citrate equivalent to 1,000 micrograms fentanyl. 1 puff (100 microlitre) contains 100 micrograms fentanyl.

200 micrograms/dose: 1 ml contains fentanyl citrate equivalent to 2,000 micrograms fentanyl. 1 puff (100 microlitre) contains 200 micrograms fentanyl.

The other ingredients are sodium dihydrogen phosphate dihydrate, disodium phosphate dihydrate, and purified water

What Instanyl looks like and contents of the pack

Instanyl is a clear, colourless nasal spray, solution. It is contained in a brown glass bottle with a metering pump.

The nasal spray is supplied in a child-resistant outer box and comes in three different pack sizes: 1.8 ml (equal to 10 doses), 2.9 ml (equal to 20 doses) and 5.0 ml (equal to 40 doses).

Not all pack sizes may be marketed.

The labelling of the three Instanyl strengths is differentiated by colour:

50 micrograms/dose labelling is orange

100 micrograms/dose labelling is purple

200 micrograms/dose labelling is greenish-blue.

Marketing Authorisation Holder

Nycomed Danmark ApS

Langebjerg 1

DK-4000 Roskilde

Denmark

Tel: +45 46 77 11 11

Manufacturer

Nycomed Pharma AS

Solbaervegen 5

N-2409 Elverum

Norway

Tel.: + 47 62 42 83 00

For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.

United Kingdom

Nycomed UK Ltd.

Three Globeside Business Park

Fieldhouse Lane

SL7 1HZ

Marlow Buckinghamshire

Tel: +44 (0) 1628 646400

This leaflet was last approved in 05/2009.

Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site: http://www.emea.europa.eu

6013401-1

Sulfo-Lo Topical

Generic Name: sulfur (Topical route)

SUL-fur

Commonly used brand name(s)

In the U.S.

• Liquimat


• Sastid Soap


• Sulfoam


• Sulfo-Lo


• Sulmasque


• Sulpho-Lac


• Sul-Ray Aloe Vera Acne


• Thylox Acne Treatment


• Zapzyt Cleansing

Available Dosage Forms:

• Soap


• Ointment


• Shampoo


• Liquid


• Lotion


• Cream


• Gel/Jelly


• Solution

Therapeutic Class: Antiacne

Uses For Sulfo-Lo

Sulfur is used to treat many kinds of skin disorders. Sulfur cream, lotion, ointment, and bar soap are used to treat acne. Sulfur ointment is used to treat seborrheic dermatitis and scabies. Sulfur may also be used for other conditions as determined by your doctor.

Some of these preparations are available only with your doctor's prescription.

Before Using Sulfo-Lo

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of this medicine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing use of sulfur in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of sulfur

This section provides information on the proper use of a number of products that contain sulfur. It may not be specific to Sulfo-Lo. Please read with care.

Use this medicine only as directed. Do not use it more often and do not use it for a longer period of time than recommended on the label, unless otherwise directed by your doctor.

Keep this medicine away from the eyes. If you should accidentally get some in your eyes, flush them thoroughly with water.

To use the cream or lotion form of this medicine:

• Before applying the medicine, wash the affected areas with soap and water and dry thoroughly. Then apply enough medicine to cover the affected areas and rub in gently.

To use the ointment form of this medicine for seborrheic dermatitis:

• Before applying the medicine, wash the affected areas with soap and water and dry thoroughly. Then apply enough medicine to cover the affected areas and rub in gently.

To use the ointment form of this medicine for scabies:

• Before applying the medicine, wash your entire body with soap and water and dry thoroughly.


• At bedtime, apply enough medicine to cover your entire body from the neck down and rub in gently. Leave the medicine on your body for 24 hours.


• Before applying the medicine again, you may wash your entire body.


• 24 hours after the last treatment with this medicine, it is important that you thoroughly wash your entire body again.

To use the soap form of this medicine:

• Work up a rich lather with the soap, using warm water. Wash the affected areas and rinse thoroughly. Apply again, and rub in gently for a few minutes. Remove excess lather with a towel or tissue without rinsing.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For acne:
  
  • For cream and bar soap dosage forms:
    
    • Adults and children—Use on the skin as needed.
    
    
  
  
  • For lotion dosage form:
    
    • Adults and children—Use two or three times a day.
    
    
  
  
  • For ointment dosage form:
    
    • Adults and children—Use the 0.5% ointment on the skin as needed.
    
    
  
  


• For seborrheic dermatitis:
  
  • For ointment dosage form:
    
    • Adults and children—Use the 5 to 10% ointment one or two times a day.
    
    
  
  


• For scabies:
  
  • For ointment dosage form:
    
    • Adults and children—Use the 6% ointment each night for three nights.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Sulfo-Lo

When using sulfur, do not use any of the following preparations on the same affected area as this medicine, unless otherwise directed by your doctor:

• Abrasive soaps or cleansers


• Alcohol-containing preparations


• Any other topical acne preparation or preparation containing a peeling agent (for example, benzoyl peroxide, resorcinol, salicylic acid, or tretinoin [vitamin A acid])


• Cosmetics or soaps that dry the skin


• Medicated cosmetics


• Other topical medicine for the skin

To use any of the above preparations on the same affected area as sulfur may cause severe irritation of the skin.

Do not use any topical mercury-containing preparation, such as ammoniated mercury ointment, on the same area as this medicine. To do so may cause a foul odor, may be irritating to the skin, and may stain the skin black. If you have any questions about this, check with your health care professional.

Sulfo-Lo Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Skin irritation not present before use of this medicine

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Redness and peeling of skin (may occur after a few days)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Sulfo-Lo Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Sulfo-Lo Topical resources

• Sulfo-Lo Topical Side Effects (in more detail)
• Sulfo-Lo Topical Use in Pregnancy & Breastfeeding
• Sulfo-Lo Topical Drug Interactions
• Sulfo-Lo Topical Support Group
• 0 Reviews for Sulfo-Lo Topical - Add your own review/rating

Compare Sulfo-Lo Topical with other medications

• Acne

Pantoprazole Delayed-Release Tablets

Pronunciation: pan-TOE-pra-zole
Generic Name: Pantoprazole
Brand Name: Protonix

Pantoprazole Delayed-Release Tablets are used for:

Treating irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.

Pantoprazole Delayed-Release Tablets are a proton pump inhibitor. It works by decreasing the amount of acid produced in the stomach.

Do NOT use Pantoprazole Delayed-Release Tablets if:

• you are allergic to any ingredient in Pantoprazole Delayed-Release Tablets


• you are taking dasatinib or certain HIV protease inhibitors (eg, atazanavir)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pantoprazole Delayed-Release Tablets:

Some medical conditions may interact with Pantoprazole Delayed-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have low blood potassium or magnesium levels, liver problems, or stomach or bowel cancer


• if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)

Some MEDICINES MAY INTERACT with Pantoprazole Delayed-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased


• Clarithromycin or voriconazole because they may increase the risk of Pantoprazole Delayed-Release Tablets's side effects


• Anticoagulants (eg, warfarin) or digoxin because the risk of their side effects may be increased by Pantoprazole Delayed-Release Tablets


• Ampicillins, azole antifungals (eg, ketoconazole), clopidogrel, dasatinib, HIV protease inhibitors (eg, atazanavir, indinavir), iron, mycophenolate, or nilotinib because their effectiveness may be decreased by Pantoprazole Delayed-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pantoprazole Delayed-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pantoprazole Delayed-Release Tablets:

Use Pantoprazole Delayed-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Pantoprazole Delayed-Release Tablets by mouth with or without food.


• Swallow Pantoprazole Delayed-Release Tablets whole. Do not break, crush, or chew before swallowing.


• You may take antacids while you are using Pantoprazole Delayed-Release Tablets if you are directed to do so by your doctor.


• If you also take an imidazole antifungal (eg, ketoconazole), take it at least 2 hours before taking Pantoprazole Delayed-Release Tablets.


• If you also take sucralfate, take Pantoprazole Delayed-Release Tablets at least 30 minutes before taking sucralfate.


• Continue to take Pantoprazole Delayed-Release Tablets even if you feel well. Do not miss any doses.


• If you miss a dose of Pantoprazole Delayed-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pantoprazole Delayed-Release Tablets.

Important safety information:

• Pantoprazole Delayed-Release Tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Pantoprazole Delayed-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.


• Pantoprazole Delayed-Release Tablets may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use Pantoprazole Delayed-Release Tablets in high doses, for longer than a year, or if you are over 50 years old. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Contact your doctor if you have any questions about this information.


• Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking Pantoprazole Delayed-Release Tablets for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).


• Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use Pantoprazole Delayed-Release Tablets.


• Pantoprazole Delayed-Release Tablets may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Pantoprazole Delayed-Release Tablets.


• Pantoprazole Delayed-Release Tablets should be used with caution in Asian patients; the risk of side effects may be increased in these patients.


• Use Pantoprazole Delayed-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.


• Pantoprazole Delayed-Release Tablets should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pantoprazole Delayed-Release Tablets while you are pregnant. Pantoprazole Delayed-Release Tablets are found in breast milk. Do not breast-feed while taking Pantoprazole Delayed-Release Tablets.

Possible side effects of Pantoprazole Delayed-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, throat, or tongue; unusual hoarseness); bone pain; chest pain; dark urine; fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; unusual bruising or bleeding; unusual tiredness; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pantoprazole side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Pantoprazole Delayed-Release Tablets:

Store Pantoprazole Delayed-Release Tablets between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pantoprazole Delayed-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Pantoprazole Delayed-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Pantoprazole Delayed-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pantoprazole Delayed-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Pantoprazole resources

• Pantoprazole Side Effects (in more detail)
• Pantoprazole Dosage
• Pantoprazole Use in Pregnancy & Breastfeeding
• Drug Images
• Pantoprazole Drug Interactions
• Pantoprazole Support Group
• 35 Reviews for Pantoprazole - Add your own review/rating

Compare Pantoprazole with other medications

• Barrett's Esophagus
• Duodenal Ulcer
• Erosive Esophagitis
• GERD
• Helicobacter Pylori Infection
• Peptic Ulcer
• Stomach Ulcer
• Stress Ulcer Prophylaxis
• Zollinger-Ellison Syndrome